Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease.

OBJECTIVE: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer's disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C-PiB). In contrast, [18F]fluoro-2-deoxy-d-glucose (18F-FDG) is a neurodegeneration biomarker used to evaluate cerebral glucose metabolism, indicating neuronal injury and synaptic dysfunction. In addition, early cerebral uptake of amyloid-PET tracers can determine regional cerebral blood flow. The present study compared early-phase 11C-PiB and 18F-FDG in older adults without cognitive impairment, amnestic mild cognitive impairment, and clinical diagnosis of probable Alzheimer's disease. METHODS: We selected 90 older adults, clinically classified as healthy controls, with amnestic mild cognitive impairment, or with probable Alzheimer's disease, who underwent an 18F-FDG PET, early-phase 11C-PiB PET and magnetic resonance imaging. All participants were also classified as amyloid-positive or -negative in late-phase 11C-PiB. The data were analyzed using statistical parametric mapping. RESULTS: We found that the probable Alzheimer's disease and amnestic mild cognitive impairment group had lower early-phase 11C-PiB uptake in limbic structures than 18F-FDG uptake. The images showed significant interactions between amyloid-beta status (negative or positive). However, early-phase 11C-PiB appears to provide different information from 18F-FDG about neurodegeneration. CONCLUSIONS: Our study suggests that early-phase 11C-PiB uptake correlates with 18F-FDG, irrespective of the particular amyloid-beta status. In addition, we observed distinct regional distribution patterns between both biomarkers, reinforcing the need for more robust studies to investigate the real clinical value of early-phase amyloid-PET imaging.

Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease

Objective: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer's disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C-PiB). In contrast, [18F]fluoro-2-deoxy-d-glucose (18F-FDG) is a neurodegeneration biomarker used to evaluate cerebral glucose metabolism, indicating neuronal injury and synaptic dysfunction. In addition, early cerebral uptake of amyloid-PET tracers can determine regional cerebral blood flow. The present study compared early-phase 11C-PiB and 18F-FDG in older adults without cognitive impairment, amnestic mild cognitive impairment, and clinical diagnosis of probable Alzheimer's disease. Methods: We selected 90 older adults, clinically classified as healthy controls, with amnestic mild cognitive impairment, or with probable Alzheimer's disease, who underwent an 18F-FDG PET, early-phase 11C-PiB PET and magnetic resonance imaging. All participants were also classified as amyloid-positive or -negative in late-phase 11C-PiB. The data were analyzed using statistical parametric mapping. Results: We found that the probable Alzheimer's disease and amnestic mild cognitive impairment group had lower early-phase 11C-PiB uptake in limbic structures than 18F-FDG uptake. The images showed significant interactions between amyloid-beta status (negative or positive). However, early-phase 11C-PiB appears to provide different information from 18F-FDG about neurodegeneration. Conclusions: Our study suggests that early-phase 11C-PiB uptake correlates with 18F-FDG, irrespective of the particular amyloid-beta status. In addition, we observed distinct regional distribution patterns between both biomarkers, reinforcing the need for more robust studies to investigate the real clinical value of early-phase amyloid-PET imaging.

Episodic Memory, Hippocampal Volume, and Function for Classification of Mild Cognitive Impairment Patients Regarding Amyloid Pathology.

BACKGROUND: Previous studies of hippocampal function and volume related to episodic memory deficits in patients with amnestic mild cognitive impairment (aMCI) have produced mixed results including increased or decreased activity and volume. However, most of them have not included biomarkers, such as amyloid-ß (Aß) deposition which is the hallmark for early identification of the Alzheimer's disease continuum. OBJECTIVE: We investigated the role of Aß deposition, functional hippocampal activity and structural volume in aMCI patients and healthy elderly controls (HC) using a new functional MRI (fMRI) ecological episodic memory task. METHODS: Forty-six older adults were included, among them Aß PET PIB positive (PIB+) aMCI (N = 17), Aß PET PIB negative (PIB-) aMCI (N = 15), and HC (N = 14). Hippocampal volume and function were analyzed using Freesurfer v6.0 and FSL for news headlines episodic memory fMRI task, and logistic regression for group classification in conjunction with episodic memory task and traditional neuropsychological tests. RESULTS: The aMCI PIB+ and PIB-patients showed significantly worse performance in relation to HC in most traditional neuropsychological tests and within group difference only on story recall and the ecological episodic memory fMRI task delayed recall. The classification model reached a significant accuracy (78%) and the classification pattern characterizing the PIB+ included decreased left hippocampal function and volume, increased right hippocampal function and volume, and worse episodic memory performance differing from PIB-which showed increased left hippocampus volume. CONCLUSION: The main findings showed differential neural correlates, hippocampal volume and function during episodic memory in aMCI patients with the presence of Aß deposition.

Adenocarcinoma of mammary origin in the maxillary gingiva: a case report and brief literature review.

Maxillofacial metastases are rare but represent advanced disease progression and a poor prognosis. The primary purpose of this article is to describe a patient with previously diagnosed and treated invasive ductal breast carcinoma who developed a metastatic lesion in the maxillary gingiva. In addition, this article presents a brief literature review of case reports on metastatic breast cancer manifestations in the gingiva. In the present case, a 68-year-old woman had been diagnosed and treated for invasive ductal breast carcinoma. At the 6-month follow-up after treatment for breast cancer, she complained of pain in the right leg and spine, swelling in the right arm associated with redness, and a nodular growth in the maxillary gingiva that was painful, friable, and associated with tooth mobility. Imaging examinations and microscopic analysis of an oral biopsy specimen revealed disease progression to the oral cavity, femur, lung, and brain. Because of the advanced disease, the patient died within a few weeks. The literature review identified 6 articles that reported varied clinical presentations of metastatic breast cancer in the gingiva. Invasive ductal carcinoma was the most common histologic type. Routine dental follow-up of patients with cancer is essential for the identification and diagnosis of oral lesions to ensure early intervention for lesions that may be distant metastases mimicking benign lesions.

Brief Report: Young Age and Sex Work Are Associated With HIV Seroconversion Among Transgender Women in São Paulo, Brazil.

BACKGROUND: Transgender women worldwide have the highest prevalence of HIV and the lowest access to prevention among groups at risk of HIV. However, few longitudinal studies have directly measured HIV incidence and identified predictors of HIV acquisition among transgender women. SETTING: São Paulo, Latin America's largest city. METHODS: We conducted a longitudinal study among transgender women in São Paulo. Participants were recruited by a long-chain peer referral process from May 2017 to July 2019. Those aged 18 years and older and who were HIV-negative at baseline were retested every 6 months up to 18 months. HIV incidence was calculated by dividing the number of seroconversions by the person-years (PYs) of follow-up; 95% confidence intervals (CIs) were constructed assuming a Poisson distribution. Conditional maximum likelihood ratios assessed differences in HIV incidence by risk factors. RESULTS: A racially/ethnically diverse sample of 545 HIV-negative transgender women was enrolled. In 485.5 PYs of follow-up, 13 seroconversions were observed, yielding an incidence of 2.68 per 100 PYs (95% CI: 1.43 to 4.58). HIV incidence was significantly higher among transgender women aged 18-24 years (rate ratio 3.85, 95% CI: 1.24 to 12.93) and among those who engaged in sex work in the preceding month (rate ratio 5.90, 95% CI: 1.71 to 26.62). CONCLUSIONS: HIV transmission continues at a high rate among transgender women in Brazil. Factors such as young age, lower level of education, and limited employment opportunities may lead to dependence on sex work that in turn increases HIV risk. Transgender-friendly prevention services, particularly programs delivering pre-exposure prophylaxis, are urgently needed.

Young age and sex work are associated with HIV seroconversion among transgender women in São Paulo, Brazil

Background: Transgender women worldwide have among the highest prevalence of HIV and the lowest access to prevention among groups at risk. However, few longitudinal studies have directly measured HIV incidence and identified predictors of HIV acquisition among transgender women. Setting: São Paulo, Latin America's largest city. Methods: We conducted a longitudinal study among transgender women in São Paulo. Participants were recruited by a long-chain peer referral process from May 2017 to July 2019. Those age 18 years and older and HIV-negative at baseline were retested every 6 months up to 18 months. HIV incidence was calculated by dividing the number of seroconversions by the person-years (py) of follow-up; 95% confidence intervals (CI) were constructed assuming a Poisson distribution. Conditional maximum likelihood ratios assessed differences in HIV incidence by risk factors. Results: A racial/ethnically diverse sample of 545 transgender women were enrolled. In 485.5 py of follow-up, 13 seroconversions were observed yielding an incidence of 2.68 per 100 py (95% CI 1.43­4.58). HIV incidence was significantly higher among transgender women age 18 to 24 years (rate ratio 3.85, 95% CI 1.24­12.93) and among those who engaged in sex work in the preceding month (rate ratio 5.90, 95% CI 1.71­26.62). Conclusion: HIV transmission continues at a high rate among transgender women in Brazil. Factors such as young age, lower level of education, and limited employment opportunities may lead to dependence upon sex work which in turn increase HIV risk. Transgender-friendly prevention services, particularly programs delivering pre-exposure prophylaxis (PrEP) are urgently needed.

Dermatite de contato por corticoide em pacientes com dermatite atópica / Corticosteroid contact dermatitis in patients with atopic dermatitis

Objetivo: Avaliar a sensibilização a corticoides tópicos e substâncias do teste de contato padrão e cosméticos em pacientes com dermatite atópica (DA) no Serviço de Alergia e Imunologia do HSPE-SP. Método: Estudo retrospectivo com análise de prontuário de pacientes com DA, classificados de acordo com o SCORing Atopic Dermatitis (SCORAD) em leve, moderada e grave, que foram atendidos no ambulatório de Alergia e Imunologia do HSPE-SP, submetidos a teste de contato com baterias padrão, cosméticos, corticoides, incluindo furoato de mometasona. Resultados: Após análise estatística dos dados de 51 pacientes portadores de DA, foi identificada maior prevalência no gênero feminino (73%). Pacientes com DA moderada/grave apresentaram maior positividade (62%) para pelo menos uma substância. Foram mais propensos a positivar para teste de contato, pacientes maiores de 18 anos. As substâncias que foram mais positivas na bateria padrão foram: sulfato de níquel (33%), neomicina (10%), e bicromato de potássio e cloreto de cobalto (8% cada). O sulfato de níquel foi mais positivo no gênero feminino. Três (5,9%) pacientes apresentaram positividade para teste de contato com bateria de corticoides, sendo positivas substâncias betametasona 1%, budesonida 0,01% e butirato de hidrocortisona 1%, e todos eram portadores de DA leve. Foi identificada relação entre positividade para bateria de corticoides e sulfato de níquel. Conclusão: Os testes de contato foram mais positivos em adultos. Houve maior sensibilidade para o sulfato de níquel no gênero feminino. Sensibilidade importante à neomicina na DA moderada/grave. Pacientes com alergia de contato por corticoides podem apresentar alergia a sulfato de níquel. Esse trabalho chama atenção para a porcentagem importante de pacientes com DA acometidos por alergia de contato por corticoides, sendo esse tipo alergia um problema emergente e que tem sido cada vez mais relatado na última década; porém, ainda são escassos os estudos envolvendo esse assunto.

Objective: To evaluate sensitization to topical corticosteroids and standard patch testing substances in patients with atopic dermatitis (AD) at the HSPE-SP Allergy and Immunology Department. Methods: This retrospective study assessed medical records of patients with AD, whose severity was classified as mild, moderate or severe according to SCORing Atopic Dermatitis (SCORAD). They were seen at the HSPE-SP Allergy and Immunology outpatient clinic and underwent a patch test with the following series: standard, cosmetics, and corticosteroids, including mometasone furoate. Results: After statistical analysis of data from 51 patients with AD, a higher prevalence was identified in female participants (73%). Patients with moderate-to-severe AD had more positive results (62%) for at least one substance. Patients older than 18 years were more likely to be positive in the patch test. The substances that were most frequently positive in the standard series were nickel sulfate (33%), neomycin (10%) and potassium dichromate and cobalt chloride (8% each). Positive nickel sulfate was more common in female participants. Three (5.9%) patients were positive for corticosteroids (1% betamethasone, 0.01% budesonide and 1% hydrocortisone butyrate) and all had mild AD. A relationship between positivity for corticosteroid series and nickel sulfate was identified. Conclusion: Patch tests were more frequently positive in adults. There was higher sensitivity to nickel sulfate in female patients. There was important sensitivity to neomycin in patients with moderate-to-severe AD. Patients with corticosteroid contact allergy may present with allergy to nickel sulfate. This paper draws attention to the important percentage of patients with AD affected by corticosteroid contact allergy, which has become an emerging problem that has been increasingly reported in the past decade. However, there are still few studies addressing this topic.

Twice-daily red and blue light treatment for Candida albicans biofilm matrix development control.

Phototherapy has been proposed as a direct means of affecting local bacterial infections. However, the use of phototherapy to prevent fungal biofilm development has received comparatively less attention. This study aimed to determine the effects of red light treatment and blue light treatment, without a photosensitizer, on the development of Candida albicans biofilm. During the development of 48-h biofilms of C. albicans SN 425 (n = 10), the biofilms were exposed twice-daily to noncoherent blue and red light (LumaCare; 420 nm and 635 nm). The energy density applied was 72 J cm-2 for blue light and 43.8 J cm2, 87.6 J cm2, and 175.5 J cm2 for red light. Positive control (PC) and negative control (NC) groups were treated twice-daily for 1 min with 0.12% chlorhexidine (CHX) and 0.89% NaCl respectively. Biofilms were analyzed for colony forming units (CFU), dry-weight, and exopolysaccharides (EPS-soluble and EPS-insoluble). Data was analyzed by one-way ANOVA and Tukey post hoc test (α = 0.05). Dry-weight was lower than NC (p < 0.001) and approached PC levels with both red and blue light treatments. CFU were also lower in groups exposed to blue light and higher durations of red light (p < 0.05). EPS-soluble and EPS-insoluble measures were variably reduced by these light exposures. In conclusion, twice-daily exposure to both blue and red lights affect the biofilm development and physiology of polysaccharide production and are potential mechanisms for the control of C. albicans biofilm matrix development.

Multidimensional effects of voice therapy in patients affected by unilateral vocal fold paralysis due to cancer / Efeitos multidimensionais da terapia vocal em pacientes com paralisia unilateral daprega vocal por câncer

Abstract Introduction: Patients with unilateral vocal fold paralysis may demonstrate different degrees of voice perturbation depending on the position of the paralyzed vocal fold. Understanding the effectiveness of voice therapy in this population may be an important coefficient to define the therapeutic approach. Objective: To evaluate the voice therapy effectiveness in the short, medium and long-term in patients with unilateral vocal fold paralysis and determine the risk factors for voice rehabilitation failure. Methods: Prospective study with 61 patients affected by unilateral vocal fold paralysis enrolled. Each subject had voice therapy with an experienced speech pathologist twice a week. A multidimensional assessment protocol was used pre-treatment and in three different times after voice treatment initiation: short-term (1-3 months), medium-term (4-6 months) and long-term (12 months); it included videoendoscopy, maximum phonation time, GRBASI scale, acoustic voice analysis and the portuguese version of the voice handicap index. Results: Multiple comparisons for GRBASI scale and VHI revealed statistically significant differences, except between medium and long term (p < 0.005). The data suggest that there is vocal improvement over time with stabilization results after 6 months (medium term). From the 28 patients with permanent unilateral vocal fold paralysis, 18 (69.2%) reached complete glottal closure following vocal therapy (p = 0.001). The logistic regression method indicated that the Jitter entered the final model as a risk factor for partial improvement. For every unit of increased Jitter, there was an increase of 0.1% (1.001) of the chance for partial improvement, which means an increase on no full improvement chance during rehabilitation. Conclusion: Vocal rehabilitation improves perceptual and acoustic voice parameters and voice handicap index, besides favor glottal closure in patients with unilateral vocal fold paralysis. The results were also permanent during the period of 1 year. The Jitter value, when elevated, is a risk factor for the voice therapy success.

Resumo Introdução: Pacientes com paralisia unilateral de prega vocal podem apresentar diferentes graus de distúrbios da voz, dependendo da posição da prega vocal paralisada. A compreensão da eficácia da terapia vocal nesta população pode ser um coeficiente importante para definir a abordagem terapêutica. Objetivo: Avaliar a eficácia da terapia vocal em curto, médio e longo prazos em pacientes com paralisia unilateral de prega vocal e determinar os fatores de risco para falha na reabilitação da voz. Método: Estudo prospectivo, no qual 61 pacientes com paralisia unilateral de prega vocal foram recrutados. Cada participante foi submetido a terapia vocal com um fonoaudiólogo experiente duas vezes por semana. Um protocolo de avaliação multidimensional foi utilizado no pré-tratamento e em três momentos após o início da terapia da voz: curto prazo (1-3 meses), médio prazo (4-6 meses) e longo prazo (12 meses); incluiu videoendoscopia, tempo máximo de fonação, escala GRBASI, análise de voz acústica e a versão em português do Voice Handicap Index. Resultados: Os dados comparativos temporais das avaliações revelaram diferenças estatisticamente significativas, exceto entre médio e longo prazo (p < 0,005). Os dados sugerem que há melhora vocal ao longo do tempo com resultados de estabilização após seis meses (médio prazo). Dos 28 pacientes com paralisia unilateral permanente da prega vocal, 18 (69,2%) atingiram o fechamento glótico completo após a terapia vocal (p = 0,001). O método de regressão logística indicou que o Jitter entrou no modelo final como um fator de risco para melhora parcial. Para cada unidade de aumento de Jitter, houve um aumento de 0,1% (1,001) da chance de melhora parcial, o que significa um aumento na chance de não ocorrer melhora completa durante a reabilitação. Conclusão: A reabilitação vocal melhora os parâmetros de voz perceptiva e acústica e o índice de incapacidade vocal, além de favorecer o fechamento glótico em pacientes com paralisia unilateral da prega vocal. Além disso, os resultados também foram permanentes durante o período de um ano. O valor de Jitter, quando elevado, é um fator de risco para sucesso parcial da terapia vocal.

Multidimensional effects of voice therapy in patients affected by unilateral vocal fold paralysis due to cancer.

INTRODUCTION: Patients with unilateral vocal fold paralysis may demonstrate different degrees of voice perturbation depending on the position of the paralyzed vocal fold. Understanding the effectiveness of voice therapy in this population may be an important coefficient to define the therapeutic approach. OBJECTIVE: To evaluate the voice therapy effectiveness in the short, medium and long-term in patients with unilateral vocal fold paralysis and determine the risk factors for voice rehabilitation failure. METHODS: Prospective study with 61 patients affected by unilateral vocal fold paralysis enrolled. Each subject had voice therapy with an experienced speech pathologist twice a week. A multidimensional assessment protocol was used pre-treatment and in three different times after voice treatment initiation: short-term (1-3 months), medium-term (4-6 months) and long-term (12 months); it included videoendoscopy, maximum phonation time, GRBASI scale, acoustic voice analysis and the portuguese version of the voice handicap index. RESULTS: Multiple comparisons for GRBASI scale and VHI revealed statistically significant differences, except between medium and long term (p<0.005). The data suggest that there is vocal improvement over time with stabilization results after 6 months (medium term). From the 28 patients with permanent unilateral vocal fold paralysis, 18 (69.2%) reached complete glottal closure following vocal therapy (p=0.001). The logistic regression method indicated that the Jitter entered the final model as a risk factor for partial improvement. For every unit of increased Jitter, there was an increase of 0.1% (1.001) of the chance for partial improvement, which means an increase on no full improvement chance during rehabilitation. CONCLUSION: Vocal rehabilitation improves perceptual and acoustic voice parameters and voice handicap index, besides favor glottal closure in patients with unilateral vocal fold paralysis. The results were also permanent during the period of 1 year. The Jitter value, when elevated, is a risk factor for the voice therapy success.

Levantamento do perfil sociodemográfico dos pacientes atendidos na rede de saúde mental de Guaíba / Survey of the sociodemographic profile of patients attended in the mental health network of Guaíba

O estudo tem como objetivo descrever o perfil sociodemográfico dos pacientes ativos atendidos em três serviços oferecidos pela rede de saúde mental do município de Guaíba, em 2016. Participaram da coleta de dados: um Centro de Atenção Psicossocial (CAPS II), um CAPS AD e uma Clínica­Escola (CESAP), do Curso de Psicologia da Universidade Luterana do Brasil. Realizou-se um levantamento de 958 prontuários dos quais se obtiveram características da população como, por exemplo: os dados nosológicos, a origem dos encaminhamentos, os principais motivos da procura pelos serviços, as principais drogas utilizadas, bem como importantes variáveis familiares e da rede social de apoio aos pacientes. A partir desses resultados, as práticas em saúde mental coletiva poderão ser potencializadas e redirecionadas visando maior eficácia, efetividade e melhoria na vida dos usuários.(AU)

The objective of this paper is to describe the sociodemographic profile of the active patients attended by three services offered by the health mental network from the city of Guaíba, in 2016. Participated in the data collection were: a Psychosocial Care Center (CAPS II), a CAPS AD and a Clinic-School (CESAP) of the Psychology Course of the University of the Lutheran Church of Brazil. A survey of 958 medical records was carried out, from which the characteristics of the population were obtained, such as: nosological data, origin of referrals, main reasons of the search for help, main drugs used, as well as important family variables and the social support network of patients. From these results, the practices in collective mental health can be enhanced and redirected aiming at greater effectiveness, effectiveness and improvement of the users' lives.(AU)

Prefrontal-Parietal White Matter Volumes in Healthy Elderlies Are Decreased in Proportion to the Degree of Cardiovascular Risk and Related to Inhibitory Control Deficits.

Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups. Findings remained significant after accounting for the presence of the APOEε4 allele. Inhibitory control performance was negatively related to right prefrontal WM volume, proportionally to the degree of CVR. Significantly reduced deep parietal WM was also detected bilaterally in the high CVR subgroup. This is the first large study documenting the topography of CVR-related WM brain volume deficits. The significant association regarding poor response inhibition indicates that prefrontal WM deficits related to CVR are clinically meaningful, since inhibitory control is known to rely on prefrontal integrity.

Clinical, hematological and genetic data of a cohort of children with hemoglobin SD.

INTRODUCTION: The hemoglobin FSD is very uncommon in newborn screening programs for sickle cell disease. In the program of Minas Gerais, Brazil, the clinical course of children with hemoglobin SD was observed to be heterogeneous. The objective of this study was to estimate the incidence (1999-2012) and to describe the natural history of a cohort of newborns with hemoglobin SD. METHODS: Isoelectric focusing was the primary method used in newborn screening. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to identify mutant alleles and for haplotyping. Gap-polymerase chain reaction was used to detect alpha-thalassemia. RESULTS: Eleven cases of hemoglobin S/D-Punjab and eight of Hb S-Korle Bu were detected. Other variants with hemoglobin D mobility were not identified. All hemoglobin D-Punjab and hemoglobin Korle Bu alleles were associated with haplotype I. Among the children with hemoglobin S/D-Punjab, there were four with the ß(S) CAR haplotype, six with the Benin haplotype, and one atypical. Results of laboratory tests for hemoglobin S/D-Punjab and hemoglobin S-Korle Bu were: hemoglobin 8.0 and 12.3g/dL (p-value <0.001), leukocyte count 13.9×10(9)/L and 10.5×10(9)/L (p-value=0.003), reticulocytes 7.5% and 1.0% (p-value <0.001), hemoglobin F concentration 16.1% and 6.9% (p-value=0.001) and oxygen saturation 91.9% and 97% (p-value=0.002), respectively. Only hemoglobin S/D-Punjab children had acute pain crises and needed blood transfusions or hydroxyurea. Those with the Benin ß(S) haplotype had higher total hemoglobin and hemoglobin F concentrations compared to the CAR haplotype. Transcranial Doppler was normal in all children. CONCLUSION: The clinical course and blood cell counts of children with hemoglobin S/D-Punjab were very similar to those of hemoglobin SS children. In contrast, children with hemoglobin S-Korle Bu had clinical course and blood cell counts like children with the sickle cell trait.

Saúde mental: concepções e práticas profissionais de um campo em tensão / Mental health conceptions and professional practices of a field in tension

A Reforma Psiquiátrica, atual política de saúde mental, redireciona os recursos da assistência psiquiátrica para o modelo de base comunitária, substituindo o modelo asilar. A abordagem proposta pela Reforma Psiquiátrica procura conjugar o esforço teórico e prático para a construção da Rede de Atenção Psicossocial. O presente trabalho objetivou desvelar concepções e práticas de trabalhadores da saúde mental, construídas na práxis de suas trajetórias profissionais e contextos de vida, em relação à incorporação do modelo de atenção psicossocial ou manutenção de princípios asilares, caracterizadores da tradicional prática profissional em saúde mental. Objetivou também identificar pontos de tensão, que caracterizam interesses de diferentes naturezas, como obstáculos e desafios à implementação da Reforma Psiquiátrica. A pesquisa, de natureza qualitativa, contou com 10 entrevistas de profissionais atuando na área, baseada na técnica de depoimento oral e em roteiro do tipo temático, sendo 3 enfermeiros, 3 psicólogos, 3 psiquiatras e 1 terapeuta ocupacional. Os relatos dos profissionais foram organizados em categorias gerais e específicas tendo em vista a interpretação das narrativas à luz da literatura especializada. Através dos discursos dos profissionais do campo da saúde mental é possível observar que um tensionamento ideológico marca fortemente o espaço da saúde

The Psychiatric Reform, current mental health policy, redirect the resources from psychiatric assistance to the community-based model, replacing the shelter model. The approach proposed by th Psychiatric Reform seeks to combine the theoretical and practical effort to construct the Psychosocial Attention Web. This work aimed to unveil concepts and practices of mental health workers built during their professional careers and life contexts, regarding the incorporation of the psychosocial care model or maintenance of asylums principles, which characterize the professional practice in mental health. It also aimed to identify points of tension that characterize interests of different natures, such as obstacles and challenges to the implementation of the psychiatric reform in the Brazilian context and in particular in the context of greater São Paulo, in which the survey was conducted. The qualitative research included ten interviews, based on oral testimony technique and theme type script, of which three were professional nurses, three psychologists, three psychiatrists and one occupational therapist. The professional reports were organized into general and specific categories, in view of the interpretation of the narratives in the light of the literature

Clinical, hematological and genetic data of a cohort of children with hemoglobin SD

Introduction The hemoglobin FSD is very uncommon in newborn screening programs for sickle cell disease. In the program of Minas Gerais, Brazil, the clinical course of children with hemoglobin SD was observed to be heterogeneous. The objective of this study was to estimate the incidence (1999­2012) and to describe the natural history of a cohort of newborns with hemoglobin SD. Methods Isoelectric focusing was the primary method used in newborn screening. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to identify mutant alleles and for haplotyping. Gap-polymerase chain reaction was used to detect alpha-thalassemia. Results Eleven cases of hemoglobin S/D-Punjab and eight of Hb S-Korle Bu were detected. Other variants with hemoglobin D mobility were not identified. All hemoglobin D-Punjab and hemoglobin Korle Bu alleles were associated with haplotype I. Among the children with hemoglobin S/D-Punjab, there were four with the ßS CAR haplotype, six with the Benin haplotype, and one atypical. Results of laboratory tests for hemoglobin S/D-Punjab and hemoglobin S-Korle Bu were: hemoglobin 8.0 and 12.3 g/dL (p-value <0.001), leukocyte count 13.9 × 109/L and 10.5 × 109/L (p-value = 0.003), reticulocytes 7.5% and 1.0% (p-value <0.001), hemoglobin F concentration 16.1% and 6.9% (p-value = 0.001) and oxygen saturation 91.9% and 97% (p-value = 0.002), respectively. Only hemoglobin S/D-Punjab children had acute pain crises and needed blood transfusions or hydroxyurea. Those with the Benin ßS haplotype had higher total hemoglobin and hemoglobin F concentrations compared to the CAR haplotype. Transcranial Doppler was normal in all children. Conclusion The clinical course and blood cell counts of children with hemoglobin S/D-Punjab were very similar to those of hemoglobin SS children. In contrast, children with hemoglobin S-Korle Bu had clinical course and blood cell counts like children with the sickle cell trait.

Factors that influence in the turnout in ballet dancers with knee pain / Factores que influyen en el turnout em bailarinas com dolor em lãs rodillas / Fatores que influenciam no turnout em bailarinas clássicas com dor nos joelhos

The turnout, primary gesture in classical ballet, refers the 180º of the feet. The lateral rotation provides the greatest amount of degrees necessary to perform the position perfectly. If performed improperly, it can generate problems, specialy in the knees, causing pain. The aim of this study was to evaluate the factors that influence the implementation of turnout in adolescents ballet dancers with knee pain and to compare them to the dancers without pain. Twenty three (23) ballet dancers with knee pain and 26 ballet dancers without pain were evaluated for range of motion of external rotation of the hip, muscle strength, femoral neck anteversion and static and dynamic turnout. The angles were measured with a manual goniometer, and the strength of the abductor muscle groups, external rotators and hip extensors with isometric dynamometer. The analysis was performed using ANOVA and Mann-Whitney. Range of motion of external rotation of the hip, femoral neck anteversion and muscle strength were similar between groups. The dynamic turnout was lower in ballet dancers with knee pain (p=0.02) and ballerinas with angular deficits above 10% over the static group had lower turnout under the bilateral extensor muscle group (p=0.04 and 0.03, right left) and right abductor (p=0.03). Although anatomical factors can influence the lateral rotation of the turnout, the angle decreased dynamic turnout was related to the group of dancers with pain. This suggests that training based on proximal awareness of movement can prevent and minimize burdens on the knees of classical dancers teens.

El turnout, principal gesto del ballet clásico, se refiere a la posición de 180º entre los pies. La rotación lateral de la cadera proporciona una mayor cantidad de grados necesarios para realizar la posición perfectamente. Si se realiza de forma inadecuada, puede generar compensaciones, preferentemente en las rodillas, generando dolor. El objetivo de este estudio fue evaluar los factores que influyen en la ejecución del turnout en bailarinas clásicas adolescentes con dolor en las rodillas y comparar las bailarinas y sin dolor. Se evaluaron a 23 bailarinas con dolor y 26 bailarinas sin dolor en cuanto al rango de movimiento de rotación lateral de la cadera, la fuerza muscular, a la anteversión del cuello femoral y al turnout estático y dinámico. Los ángulos fueron medidos con un goniómetro manual, y la fuerza de los grupos musculares abductores, rotadores externos y extensores de la cadera con dinamómetro isométrico. El análisis se realizó por medio del ANOVA y Mann-Whitney. El rango de movimiento, la anteversión del cuello femoral y la fuerza del músculo fueron similares entre los grupos. El turnout dinámico fue menor en el grupo de bailarinas con dolor (p=0,02), y las bailarinas con déficits angulares superiores a 10% en relación al turnout estático presentaron menor fuerza del grupo muscular de los extensores bilaterales (p=0,04 y 0,03, derecha e izquierda) y abiductores derecho (p=0,03). Aunque los factores anatómicos pueden influir en la rotación lateral del turnout, la disminución del ángulo del turnout dinámico se relacionó con el grupo de bailarinas con dolor. Tal hecho sugiere que el entrenamiento basado en la conciencia proximal del movimiento puede prevenir y minimizar las sobrecargas en las rodillas de bailarinas clásicas adolescentes.

O turnout, gesto principal do balé clássico, refere-se à posição de 180º entre os pés. A rotação lateral do quadril fornece a maior quantidade de graus necessários para realizar a posição com perfeição. Se executada de forma inadequada, pode gerar compensações, preferencialmente nos joelhos, ocasionando dor. O objetivo deste estudo foi avaliar fatores que influenciam na execução do turnout em bailarinas clássicas adolescentes com dor nos joelhos e comparar a bailarinas sem dor. Foram avaliadas 23 bailarinas com dor e 26 bailarinas sem dor quanto à amplitude de movimento de rotação lateral do quadril, força muscular, à anteversão do colo femoral e ao turnout estático e dinâmico. Os ângulos foram mensurados com goniômetro manual, e a força dos grupos musculares abdutores, rotadores laterais e extensores do quadril com dinamômetro isométrico. A análise foi feita por meio do ANOVA e Mann-Whitney. A amplitude de movimento, a anteversão do colo femoral e a força muscular foram semelhantes entre os grupos. O turnout dinâmico foi menor no grupo de bailarinas com dor (p=0,02), e bailarinas com déficits angulares acima 10% em relação ao turnout estático apresentaram menor força do grupo muscular dos extensores bilateral (p=0,04 e 0,03, direita e esquerda) e abdutores direito (p=0,03). Embora fatores anatômicos possam influenciar na rotação lateral do turnout, a diminuição angular do turnout dinâmico esteve mais relacionada ao grupo de bailarinas com dor. Tal fato sugere que o treinamento baseado na conscientização proximal do movimento pode prevenir e minimizar as sobrecargas nos joelhos de bailarinas clássicas adolescentes.

Análise do SICK Scapula em jogadores de handebol com e sem dor no ombro durante o arremesso / Analysis of the sick scapula in handball players with and without shoulder pain during throwing / Análisis del sick scapula en jugadores de handbol con y sin dolor en el hombro durante el lanzamiento

INTRODUÇÃO: A discinesia escapular é definida como uma alteração da posição escapular, tanto dinâmica quanto estática, resultante de desequilíbrios da musculatura periescapular secundários à fadiga, trauma ou lesão neurológica. O SICK Scapula avalia e caracteriza as alterações escapulares estaticamente, variando de 0 a 20 pontos (0 = melhor possível). No exame, a escápula é avaliada em três aspectos: dor objetiva, dor subjetiva e mau posicionamento escapular. OBJETIVO: Comparar o SICK Scapula entre jogadores de handebol sintomáticos e assintomáticos. MÉTODOS: A amostra foi composta por 57 atletas de handebol divididos em dois grupos, de acordo com a presença de dor no ombro: grupo assintomático (GA) (N = 27) e grupo sintomático (GS) (N = 30). O SICK Scapula foi avaliado entre os atletas, tanto em relação à sua pontuação final como às subescalas. O GS apresentou maior pontuação no SICK Scapula em relação ao GA (8 ± 2,3 vs 2,7 ± 1,8; p<0,001). RESULTADOS: Nas subescalas, os GA e GS também apresentaram diferenças significantes quanto à dor subjetiva (0 vs. 1,73 ± 0,83; p < 0,001), dor objetiva (0,41 ± 0,64 vs. 2,5 ±0,86; p < 0,001) e mau posicionamento escapular (2,3 ± 1,9 vs. 3,7 ± 1,5; p = 0,002). CONCLUSÃO: Os atletas de handebol com dor relacionada ao arremesso apresentam maior pontuação com relação à dor e às alterações de posicionamento escapular, segundo avaliação pelo SICK Scapula, em comparação com os que não apresentam sintomatologia. .

INTRODUCTION: The scapular dyskinesia is defined as a change in scapular position, both dynamic and static, resulting from periscapular imbalances secondary to muscle fatigue, trauma or neurological injury. The SICK Scapula statically evaluates and characterizes the scapular changes, ranging from 0 to 20 (0 = best). This exam addressed three aspects: objective pain, subjective pain and scapular malposition. OBJECTIVE: To compare the SICK Scapula in symptomatic and asymptomatic handball players. METHODS: The sample consisted of 57 handball athletes divided into two groups according to the presence of shoulder pain: asymptomatic group (AG) (N = 27) and symptomatic group (SG) (N = 30). The SICK Scapula score has been reported among athletes, both in relation to the total score and its subscales. The GS had a significantly higher score than the GA (8±2.3 vs. 2.7±1.8; p<0.001). RESULTS: In the subscales, GA and SG also showed significant differences in subjective pain (0 vs. 1.73±0.83, p<0.001), objective pain (0.41±0.64 vs. 2.5±0.86, p<0.001) and scapular malposition (2.3±1.9 vs. 3.7±1.5, p=0.002). CONCLUSION: The handball athletes with throwing-related pain have a higher score with respect to pain and changes of scapular positioning, as assessed by SICK Scapula, compared with those who did not have symptoms. .

INTRODUCCIÓN: La discinesia escapular es definida como una alteración de la posición escapular, tanto dinámica como estática, resultante de desequilibrios de la musculatura periescapular secundarios a la fatiga, trauma o lesión neurológica. El SICK Scapula evalúa y caracteriza las alteraciones escapulares estáticamente, variando de 0 a 20 puntos (0 = mejor posible). En el examen, la escápula es evaluada en tres aspectos: dolor objetivo, dolor subjetivo y mal posicionamiento escapular. OBJETIVO: Comparar el SICK Scapula entre jugadores de handbol sintomáticos y asintomáticos. MÉTODOS: La muestra fue compuesta por 57 atletas de handbol divididos en dos grupos, de acuerdo con la presencia de dolor en el hombro: grupo asintomático (GA) (N = 27) y grupo sintomático (GS) (N = 30). El SICK Scapula fue evaluado entre los atletas, tanto en relación a su puntuación final como a las subescalas. GS presentó mayor puntuación en el SICK Scapula en relación al GA (8 ± 2,3 vs 2,7 ± 1,8; p<0,001). RESULTADOS: En las subescalas, los GA y GS también presentaron diferencias significativas sobre el Dolor Subjetivo (0 vs. 1,73 ± 0,83; p < 0,001), Dolor Objetivo (0,41 ± 0,64 vs. 2,5 ±0,86; p < 0,001) y mal posicionamiento escapular (2,3 ± 1,9 vs. 3,7 ± 1,5; p = 0,002). CONCLUSIÓN: Los atletas de handbol con dolor relacionado al lanzamiento presentan mayor puntuación con relación al dolor y a las alteraciones de posicionamiento escapular, según evaluación por el SICK Scapula, en comparación con los que no presentan sintomatología. .

Glenohumeral range of motion in handball players with and without throwing-related shoulder pain.

BACKGROUND: Overhead athletes are subject to adaptations in the shoulder including glenohumeral internal rotation deficit (GIRD). It has been documented that this alteration is more evident in overhead athletes with pain. Our objective was to compare glenohumeral rotation motion between symptomatic and asymptomatic handball players. MATERIALS AND METHODS: Glenohumeral rotation range of motion, GIRD, external rotation gain (ERG), and total rotation motion were determined with a standard goniometer in 30 handball players with pain and 27 without pain. Differences between the throwing and non-throwing shoulder were determined in each group. RESULTS: Handball players with pain had significantly greater GIRD (P = .002), ERG (P = .027), and external rotation in the throwing arm (P = .042) and lesser internal rotation in the throwing arm (P = .029) in comparison to the athletes without pain. Comparisons between limbs exhibited a significant difference in the 2 groups regarding internal and external rotation (P < .02), but differences within the group with pain were greater. Differences were not found in the total rotation motion between the 2 groups. CONCLUSION: Handball players showed specific adaptations in the throwing shoulder; in particular, handball players with pain have greater GIRD, ERG, and external rotation and lesser internal rotation of the throwing shoulder.

Sentimento de gratidão em crianças de 5 a 12 anos / El sentimiento de gratitud en niños de 5 a 12 años / The feeling of gratitude in 5- to 12-year-old children

Apresentam-se resultados de um estudo sobre o desenvolvimento do sentimento de gratidão na infância. Os participantes foram 12 crianças, igualmente distribuídas em três grupos etários (5-6, 7-8 e 11-12 anos) e por sexo. Utilizaram-se três histórias sobre situações hipotéticas, as quais enfocam diferentes tipos de ação benevolente. Após cada história, realizou-se uma entrevista clínica com a criança. Os resultados sugerem uma diferença entre os grupos etários quanto aos tipos de sentimento positivo atribuídos ao beneficiário da ação. Embora pouco referida pelos participantes, a consideração da mudança do estado sentimental do beneficiário parece contribuir para a compreensão da gratidão. Os resultados indicam ainda que existem diferenças significativas entre os três grupos etários quanto ao tipo de relação estabelecido entre a satisfação experienciada pelo beneficiário e o benfeitor. Os dados encontrados, discutidos à luz da literatura, sugerem novas questões de pesquisa.(AU)

Results are presented from a study about the development of the feeling of gratitude in childhood. The participants were 12 children, distributed equally across three age groups (5-6, 7-8, and 11-12 years) and by sex. The study used three stories about hypothetical situations, each focusing on a different type of benevolent action. Following each story, a clinical interview was conducted with each child. The results suggest a difference among the age groups in terms of the types of positive feeling attributed to the beneficiary of the action. Although few participants referred explicitly to this, considering the beneficiary's changed feeling state appears to contribute to the understanding of gratitude. The results reveal significant differences among the three age groups in the types of relation established between the satisfaction felt by the beneficiary and the benefactor. These results, discussed in light of the literature, suggest new research questions.(AU)

Se presentan los resultados de un estudio sobre el desarrollo del sentimiento de gratitud en la infancia. Los participantes fueron 12 niños, igualmente distribuidos en tres grupos etarios (5-6, 7-8 y 11-12 años) y por sexo. Se utilizaron tres historias sobre situaciones hipotéticas en las cuales se enfocan diferentes tipos de acciones benevolentes. Después de cada historia, se ha hecho una entrevista clínica con cada niño. Los resultados sujeren una diferencia entre los grupos etarios en relación a los tipos de sentimiento positivo atribuidos al beneficiario de la acción. Aunque poco referida por los participantes, la consideración del cambio del estado sentimental del beneficiario parece contribuir a la comprensión de la gratitud. Los resultados indican aun que existen diferencias significativas entre los tres grupos etarios en relación al tipo de relación establecida entre la satisfación experimentada por el beneficiario y por el bienfactor. Los datos encontrados, discutidos a la luz de la literatura, sujeren nuevas cuestiones de investigación.(AU)

Sentimento de gratidão em crianças de 5 a 12 anos / El sentimiento de gratitud en niños de 5 a 12 años / The feeling of gratitude in 5- to 12-year-old children

Apresentam-se resultados de um estudo sobre o desenvolvimento do sentimento de gratidão na infância. Os participantes foram 12 crianças, igualmente distribuídas em três grupos etários (5-6, 7-8 e 11-12 anos) e por sexo. Utilizaram-se três histórias sobre situações hipotéticas, as quais enfocam diferentes tipos de ação benevolente. Após cada história, realizou-se uma entrevista clínica com a criança. Os resultados sugerem uma diferença entre os grupos etários quanto aos tipos de sentimento positivo atribuídos ao beneficiário da ação. Embora pouco referida pelos participantes, a consideração da mudança do estado sentimental do beneficiário parece contribuir para a compreensão da gratidão. Os resultados indicam ainda que existem diferenças significativas entre os três grupos etários quanto ao tipo de relação estabelecido entre a satisfação experienciada pelo beneficiário e o benfeitor. Os dados encontrados, discutidos à luz da literatura, sugerem novas questões de pesquisa.

Results are presented from a study about the development of the feeling of gratitude in childhood. The participants were 12 children, distributed equally across three age groups (5-6, 7-8, and 11-12 years) and by sex. The study used three stories about hypothetical situations, each focusing on a different type of benevolent action. Following each story, a clinical interview was conducted with each child. The results suggest a difference among the age groups in terms of the types of positive feeling attributed to the beneficiary of the action. Although few participants referred explicitly to this, considering the beneficiary's changed feeling state appears to contribute to the understanding of gratitude. The results reveal significant differences among the three age groups in the types of relation established between the satisfaction felt by the beneficiary and the benefactor. These results, discussed in light of the literature, suggest new research questions.

Se presentan los resultados de un estudio sobre el desarrollo del sentimiento de gratitud en la infancia. Los participantes fueron 12 niños, igualmente distribuidos en tres grupos etarios (5-6, 7-8 y 11-12 años) y por sexo. Se utilizaron tres historias sobre situaciones hipotéticas en las cuales se enfocan diferentes tipos de acciones benevolentes. Después de cada historia, se ha hecho una entrevista clínica con cada niño. Los resultados sujeren una diferencia entre los grupos etarios en relación a los tipos de sentimiento positivo atribuidos al beneficiario de la acción. Aunque poco referida por los participantes, la consideración del cambio del estado sentimental del beneficiario parece contribuir a la comprensión de la gratitud. Los resultados indican aun que existen diferencias significativas entre los tres grupos etarios en relación al tipo de relación establecida entre la satisfación experimentada por el beneficiario y por el bienfactor. Los datos encontrados, discutidos a la luz de la literatura, sujeren nuevas cuestiones de investigación.